Evaluation of minimal residual disease in childhood ALL

Evaluation of Relationship between Minimal Residual Disease (MRD) and Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) Using Quantitative Fluorescent PCR

evaluation of relationship between minimal residual disease (mrd) and relapse in childhood acute lymphoblastic leukemia (all) using quantitative fluorescent pcr

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Minimal residual disease in pediatric ALL

Status of minimal residual disease testing in childhood haematological malignancies.

In children with acute leukaemia, measurements of minimal residual disease (MRD) provide unique information on treatment response and have become a crucial component of contemporary treatment protocols. In acute lymphoblastic leukaemia (ALL), the most useful MRD assays are based on polymerase chain reaction (PCR) amplification of antigen-receptor genes, and on flow cytometric detection of abnor...

Minimal residual disease in childhood acute lymphoblastic leukaemia.

Risk directed treatment forms a central component of modern protocols for childhood acute lymphoblastic leukaemia (ALL). A review of recent studies of minimal residual disease (MRD) analysis shows that it is a powerful prognostic factor in both first line and relapse treatment. However, the value of MRD analysis is both time point and protocol specific, and the threshold for MRD detection of th...